Linkage Mapping of the Rat Poly(ADP-ribose) Glycohydrolase (Parg) Gene to Chromosome 16.

Poly (ADP-ribose) glycohydrolase (PARG) and its therapeutic potential.

Poly (ADP-robose) glycohydrolase (PARG) is a catabolic enzyme that cleaves ADP-ribose polymers synthesized by members of the poly (ADP-ribose) polymerase (PARP) family of enzymes. The growing evidence supports the importance of a tight control of poly (ADP-ribose) metabolism by the two major enzymes, PARP-1 and PARG. Recent studies have advanced the understanding of PARPs' and PARG's functions ...

Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG).

The poly(ADP-ribose) (PAR) post-translational modification is essential for diverse cellular functions, including regulation of transcription, response to DNA damage, and mitosis. Cellular PAR is predominantly synthesized by the enzyme poly(ADP-ribose) polymerase-1 (PARP-1). PARP-1 is a critical node in the DNA damage response pathway, and multiple potent PARP-1 inhibitors have been described, ...

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells

After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG). Inhibition of PARG leads to a failure of DNA repair and small molecule inhibition of PARG has been a goal for many years. To determine whether biochemical inhibitors of PARG are active in cells we have designed an ...

Mapping of the serotonin transporter locus (SLC6A4) to rhesus chromosome 16 using genetic linkage.

Linkage mapping of the rat interleukin 1 receptor antagonist gene on chromosome 3.

activity of these two cytokines is neutralized. Specific alleles of the human IL1RN were found to be associated with chronic hypochlorhydric response to Helicobacter pylori infection and the risk of gastric cancer [4], and with severe clinical symptoms in several chronic inflammatory diseases, including systemic lupus erythematosus [5], ulcerative colitis [6] and alopecia areata [7]. Two SNPs w...